NFL Week 10 Game Predictions and Expert Picks (2025 Season)
Week 10 of the 2025 NFL season is here, and the playoff picture is starting to take shape. In the AFC, Denver, Indianapolis, and New England are holding strong at the top, while the NFC features a fierce race among Philadelphia, Seattle, and Los Angeles. This week’s slate features high-stakes showdowns, international action, and critical divisional battles.
Among the toughest and most exciting matchups of the week, these four games stand out — each carrying playoff-level intensity and storylines you can’t miss:
Buffalo Bills at Miami Dolphins
📺 CBS | 1:00 PM ET | Hard Rock Stadium
A high-powered AFC East showdown with huge playoff implications. Josh Allen and Tua Tagovailoa face off in a battle that could shape the division race.
Los Angeles Rams at San Francisco 49ers
📺 FOX | 4:25 PM ET | Levi’s Stadium
A fierce NFC West rivalry packed with emotion, power, and unpredictability. Expect fireworks as Stafford and Purdy go head-to-head.
Pittsburgh Steelers at Los Angeles Chargers
📺 NBC | 8:20 PM ET | SoFi Stadium
Two defensive-minded teams meet in a key AFC primetime matchup. Can Justin Herbert outlast Pittsburgh’s relentless pass rush under the bright lights?
Philadelphia Eagles at Green Bay Packers
📺 ABC/ESPN | Monday 8:15 PM ET | Lambeau Field
Cold weather, high stakes. Jalen Hurts takes on Jordan Love in what could be a preview of a January playoff showdown.
Let’s dive into all the matchups, complete with score predictions, betting insights, and reasons behind each pick.
Thursday, November 6
Las Vegas Raiders at Denver Broncos
📺 9:15 PM ET | Prime Video
🏟️ Empower Field at Mile High
Line: DEN -10.5 | O/U: 40.5
Prediction: Broncos 30, Raiders 13
Pick: Denver -10.5 | Under 40.5
Denver’s defense is playing championship-caliber football, and Russell Wilson is managing games efficiently. The Raiders’ offense lacks rhythm against a tough Denver secondary.
Sunday, November 9
Atlanta Falcons vs. Indianapolis Colts (Germany Game)
📺 9:30 AM ET | NFL Network
🏟️ Olympic Stadium, Berlin
Line: IND -6 | O/U: 49.5
Prediction: Colts 31, Falcons 23
Pick: Indianapolis -6 | Over 49.5
Anthony Richardson and Jonathan Taylor headline an explosive Colts offense. The Falcons keep it close early but fade late overseas.
New York Giants at Chicago Bears
📺 1:00 PM ET | FOX
🏟️ Soldier Field, Chicago
Line: CHI -4 | O/U: 47.5
Prediction: Bears 27, Giants 17
Pick: Chicago -4 | Under 47.5
Rookie quarterback Caleb Williams delivers another efficient outing. Chicago’s front seven dominates the trenches and forces turnovers.
Buffalo Bills at Miami Dolphins
📺 1:00 PM ET | CBS
🏟️ Hard Rock Stadium, Miami
Line: BUF -6.5 | O/U: 51.5
Prediction: Bills 34, Dolphins 26
Pick: Buffalo -6.5 | Over 51.5
Josh Allen continues his MVP push with another strong outing. Miami struggles to contain Buffalo’s balanced attack.
Baltimore Ravens at Minnesota Vikings
📺 1:00 PM ET | FOX
🏟️ U.S. Bank Stadium, Minneapolis
Line: BAL -3 | O/U: 47.5
Prediction: Ravens 27, Vikings 21
Pick: Baltimore -3 | Under 47.5
Lamar Jackson shines under pressure while Baltimore’s secondary limits Kirk Cousins’ deep threats.
Cleveland Browns at New York Jets
📺 1:00 PM ET | CBS
🏟️ MetLife Stadium, East Rutherford
Line: NYJ -1.5 | O/U: 37.5
Prediction: Jets 20, Browns 16
Pick: Jets -1.5 | Under 37.5
A defensive battle from start to finish. Aaron Rodgers plays smart, mistake-free football to edge out Cleveland.
New England Patriots at Tampa Bay Buccaneers
📺 1:00 PM ET | CBS
🏟️ Raymond James Stadium, Tampa
Line: TB -3 | O/U: 45.5
Prediction: Patriots 24, Buccaneers 23
Pick: New England +3 | Under 45.5
The Patriots’ disciplined defense frustrates Baker Mayfield, and Drake Maye shows flashes of brilliance on the road.
New Orleans Saints at Carolina Panthers
📺 1:00 PM ET | FOX
🏟️ Bank of America Stadium, Charlotte
Line: CAR -4 | O/U: 39.0
Prediction: Panthers 20, Saints 16
Pick: Saints +4 | Under 39.0
Bryce Young finds a late drive to seal the win, but both offenses struggle in a low-scoring NFC South matchup.
Jacksonville Jaguars at Houston Texans
📺 1:00 PM ET | CBS
🏟️ NRG Stadium, Houston
Line: JAX -2 | O/U: 38.5
Prediction: Jaguars 23, Texans 20
Pick: Jacksonville -2 | Under 38.5
Trevor Lawrence outduels C.J. Stroud in a pivotal AFC South clash. Jacksonville’s defense steps up in the fourth quarter.
Arizona Cardinals at Seattle Seahawks
📺 4:05 PM ET | CBS
🏟️ Lumen Field, Seattle
Line: SEA -8 | O/U: 45.0
Prediction: Seahawks 30, Cardinals 17
Pick: Seattle -8 | Over 45.0
Seattle remains dominant at home as Geno Smith connects with DK Metcalf and Tyler Lockett for big plays.
Los Angeles Rams at San Francisco 49ers
📺 4:25 PM ET | FOX
🏟️ Levi’s Stadium, Santa Clara
Line: LAR -2 | O/U: 51.5
Prediction: Rams 29, 49ers 28
Pick: 49ers +2 | Over 51.5
An NFC West thriller with offensive fireworks. Matthew Stafford and Brock Purdy trade touchdowns in a game decided by one possession.
Detroit Lions at Washington Commanders
📺 4:25 PM ET | FOX
🏟️ Commanders Field, Landover
Line: DET -7 | O/U: 49.0
Prediction: Lions 33, Commanders 20
Pick: Detroit -7 | Over 49.0
Jared Goff continues to guide one of the league’s most balanced offenses. Detroit’s defense adds a touchdown to secure the win.
Pittsburgh Steelers at Los Angeles Chargers
📺 8:20 PM ET | NBC / Peacock
🏟️ SoFi Stadium, Inglewood
Line: LAC -3.5 | O/U: 44.0
Prediction: Chargers 27, Steelers 19
Pick: Los Angeles -3.5 | Under 44.0
Justin Herbert’s precision passing leads the way, while Pittsburgh’s offense can’t keep pace in the second half.
Monday, November 10
Philadelphia Eagles at Green Bay Packers
📺 8:15 PM ET | ABC / ESPN
🏟️ Lambeau Field, Green Bay
Line: GB -2.5 | O/U: 45.0
Prediction: Eagles 28, Packers 24
Pick: Philadelphia +2.5 | Over 45.0
Jalen Hurts outduels Jordan Love in a cold-weather battle. The Eagles’ experience shines in clutch moments.
Final Thoughts:
Week 10 delivers everything — international football, divisional rivalries, and playoff positioning battles. The AFC continues to look like Denver’s to lose, while the NFC’s top tier remains wide open. Expect several close finishes and key statement wins from contenders.