The 2022 NFL Week 4 games are scheduled, to begin with, Miami will visit Cincinnati on Thursday, September 29, and ends with a game between the LA Rams vs San Francisco Monday, October 3, 2022.
Thursday, September 29
| Matchup | Time (ET) | TV |
| Miami @ Cincinnati | 8:15 PM | Prime Video |
Sunday, October 2
| Matchup | Time (ET) | TV |
| Minnesota @ New Orleans | 9:30 AM | NFLN |
| Cleveland @ Atlanta | 1:00 PM | CBS |
| Buffalo @ Baltimore | 1:00 PM | CBS |
| Washington @ Dallas | 1:00 PM | FOX |
| Seattle @ Detroit | 1:00 PM | FOX |
| LA Chargers @ Houston | 1:00 PM | CBS |
| Tennessee @ Indianapolis | 1:00 PM | FOX |
| Chicago @ NY Giants | 1:00 PM | FOX |
| Jacksonville @ Philadelphia | 1:00 PM | CBS |
| NY Jets @ Pittsburgh | 1:00 PM | CBS |
| Arizona @ Carolina | 4:05 PM | FOX |
| New England @ Green Bay | 4:25 PM | CBS |
| Denver @ Las Vegas | 4:25 PM | CBS |
| Kansas City @ Tampa Bay | 8:20 PM | NBC |
Monday, October 3
| Matchup | Time (ET) | TV |
| LA Rams @ San Francisco | 8:15 PM | ESPN |