The 2022 NFL Week 2 games is schedule to begin with the LA Chargers will visit Kansas City on Thursday, September 15 and ends with a game between the Minnesota vs Philadelphia on Thursday, September 19, 2022.
Thursday, September 15
| Matchup | Time (ET) | TV |
| LA Chargers @ Kansas City | 8:15 PM | Prime Video |
Sunday, September 18
| Matchup | Time (ET) | TV |
| Miami @ Baltimore | 1:00 PM | CBS |
| NY Jets @ Cleveland | 1:00 PM | CBS |
| Washington @ Detroit | 1:00 PM | FOX |
| Indianapolis @ Jacksonville | 1:00 PM | CBS |
| Tampa Bay @ New Orleans | 1:00 PM | FOX |
| Carolina @ NY Giants | 1:00 PM | FOX |
| New England @ Pittsburgh | 1:00 PM | CBS |
| Atlanta @ LA Rams | 4:05 PM | FOX |
| Seattle @ San Francisco | 4:05 PM | FOX |
| Cincinnati @ Dallas | 4:25 PM | CBS |
| Houston @ Denver | 4:25 PM | CBS |
| Arizona @ Las Vegas | 4:25 PM | CBS |
| Chicago @ Green Bay | 8:20 PM | NBC |
Monday, September 19
| Matchup | Time (ET) | TV |
| Tennessee @ Buffalo | 7:15 PM | ESPN |
| Minnesota @ Philadelphia | 8:30 PM | ABC |