The 2022 NFL Week 5 games are scheduled, to begin with, Indianapolis will visit Denver on Thursday, October 6, and ends with a game between the Las Vegas vs Kansas City Monday, October 10, 2022.
Thursday, October 6
| Matchup | Time (ET) | TV |
| Indianapolis @ Denver | 8:15 PM | Prime Video |
Sunday, October 9
| Matchup | Time (ET) | TV |
| NY Giants @ Green Bay | 9:30 AM | NFLN |
| Pittsburgh @ Buffalo | 1:00 PM | CBS |
| LA Chargers @ Cleveland | 1:00 PM | CBS |
| Houston @ Jacksonville | 1:00 PM | CBS |
| Chicago @ Minnesota | 1:00 PM | FOX |
| Detroit @ New England | 1:00 PM | FOX |
| Seattle @ New Orleans | 1:00 PM | FOX |
| Miami @ NY Jets | 1:00 PM | CBS |
| Atlanta @ Tampa Bay | 1:00 PM | FOX |
| Tennessee @ Washington | 1:00 PM | CBS |
| San Francisco @ Carolina | 4:05 PM | CBS |
| Philadelphia @ Arizona | 4:25 PM | FOX |
| Dallas @ LA Rams | 4:25 PM | FOX |
| Cincinnati @ Baltimore | 8:20 PM | NBC |
Monday, October 10
| Matchup | Time (ET) | TV |
| Las Vegas @ Kansas City | 8:15 PM | ESPN |