The 2022 NFL Week 3 games are scheduled to begin with the Pittsburgh will visit Cleveland on Thursday, September 22, and end with a game between the Dallas vs NY Giants on Monday, September 26, 2022.
Thursday, September 22
| Matchup | Time (ET) | TV |
| Pittsburgh @ Cleveland | 8:15 PM | Prime Video |
Sunday, September 25
| Matchup | Time (ET) | TV |
| New Orleans @ Carolina | 1:00 PM | FOX |
| Houston @ Chicago | 1:00 PM | CBS |
| Kansas City @ Indianapolis | 1:00 PM | CBS |
| Buffalo @ Miami | 1:00 PM | CBS |
| Detroit @ Minnesota | 1:00 PM | FOX |
| Baltimore @ New England | 1:00 PM | FOX |
| Cincinnati @ NY Jets | 1:00 PM | CBS |
| Las Vegas @ Tennessee | 1:00 PM | FOX |
| Philadelphia @ Washington | 1:00 PM | FOX |
| Jacksonville @ LA Chargers | 4:05 PM | CBS |
| LA Rams @ Arizona | 4:25 PM | FOX |
| Atlanta @ Seattle | 4:25 PM | FOX |
| Green Bay @ Tampa Bay | 4:25 PM | FOX |
| San Francisco @ Denver | 8:20 PM | NBC |
Monday, September 26
| Matchup | Time (ET) | TV |
| Dallas @ NY Giants | 8:15 PM | ESPN |