The 2022 NFL Week 16 games are scheduled, to begin with, Jacksonville will visit NY Jets on Thursday, December 22, and ends with a game between the LA Chargers vs Indianapolis Monday, December 26, 2022.
Thursday, December 22
| Matchup | Time (ET) | TV |
| Jacksonville @ NY Jets | 8:15 PM | Prime Video |
Saturday, December 24
| Matchup | Time (ET) | TV |
| Atlanta @ Baltimore | 1:00 PM | FOX |
| Detroit @ Carolina | 1:00 PM | FOX |
| Buffalo @ Chicago | 1:00 PM | CBS |
| New Orleans @ Cleveland | 1:00 PM | CBS |
| Seattle @ Kansas City | 1:00 PM | FOX |
| NY Giants @ Minnesota | 1:00 PM | FOX |
| Cincinnati @ New England | 1:00 PM | CBS |
| Houston @ Tennessee | 1:00 PM | CBS |
| Washington @ San Francisco | 4:05 PM | CBS |
| Philadelphia @ Dallas | 4:25 PM | FOX |
| Las Vegas @ Pittsburgh | 8:15 PM | NFLN |
Sunday, December 25
| Matchup | Time (ET) | TV |
| Green Bay @ Miami | 1:00 PM | FOX |
| Denver @ LA Rams | 4:30 PM | CBS |
| Tampa Bay @ Arizona | 8:20 PM | NBC |
Monday, December 26
| Matchup | Time (ET) | TV |
| LA Chargers @ Indianapolis | 8:15 PM | ESPN |