2022 NFL Preseason Week 2, Thursday, August 18
| Game | Time (ET) | TV | Scores |
| Seattle vs Chicago | 8:00 PM | ESPN | TBD |
2022 NFL Preseason Week 2, Friday, August 19
| Game | Time (ET) | TV | Scores |
| New England vs Carolina | 7:00 PM | Local/NFLN | TBD |
| Green Bay vs New Orleans | 8:00 PM | Local | TBD |
| LA Rams vs Houston | 10:00 PM | Local/NFLN | TBD |
2022 NFL Preseason Week 2, Saturday, August 20
| Game | Time (ET) | TV | Scores |
| Buffalo vs Denver | 1:00 PM | Local/NFLN | TBD |
| Indianapolis vs Detroit | 1:00 PM | Local | TBD |
| Kansas City vs Washington | 4:00 PM | Local/NFLN | TBD |
| Miami vs Las Vegas | 7:00 PM | Local | TBD |
| Jacksonville vs Pittsburgh | 7:00 PM | Local | TBD |
| Tennessee vs Tampa Bay | 7:00 PM | Local/NFLN | TBD |
| Minnesota vs San Francisco | 7:00 PM | Local | TBD |
| LA Chargers vs Dallas | 10:00 PM | Local/NFLN | TBD |
2022 NFL Preseason Week 2, Sunday, August 21
| Game | Time (ET) | TV | Scores |
| Cleveland vs Philadelphia | 1:00 PM | Local/NFLN | TBD |
| NY Giants vs Cincinnati | 7:00 PM | Local/NFLN | TBD |
| Arizona vs Baltimore | 8:00 PM | FOX | TBD |
2022 NFL Preseason Week 2, Monday, August 22
| Game | Time (ET) | TV | Scores |
| NY Jets vs Atlanta | 8:00 PM | ESPN | TBD |