The 2022 NFL Week 13 games are scheduled, to begin with, Buffalo will visit New England on Thursday, December 1, and ends with a game between New Orleans vs Tampa Bay Monday, December 5, 2022.
Thursday, December 1
| Matchup | Time (ET) | TV |
| Buffalo @ New England | 8:15 PM | Prime Video |
Sunday, December 4
| Matchup | Time (ET) | TV |
| Pittsburgh @ Atlanta | 1:00 PM | CBS |
| Denver @ Baltimore | 1:00 PM | CBS |
| Green Bay @ Chicago | 1:00 PM | FOX |
| Jacksonville @ Detroit | 1:00 PM | FOX |
| Cleveland @ Houston | 1:00 PM | CBS |
| NY Jets @ Minnesota | 1:00 PM | CBS |
| Washington @ NY Giants | 1:00 PM | FOX |
| Tennessee @ Philadelphia | 1:00 PM | FOX |
| Seattle @ LA Rams | 4:05 PM | FOX |
| Miami @ San Francisco | 4:05 PM | FOX |
| Kansas City @ Cincinnati | 4:25 PM | CBS |
| LA Chargers @ Las Vegas | 4:25 PM | CBS |
| Indianapolis @ Dallas | 8:20 PM | NBC |
Monday, December 5
| Matchup | Time (ET) | TV |
| New Orleans @ Tampa Bay | 8:15 PM | ESPN |