The 2022 NFL Week 1 games are scheduled to begin with the Buffalo Bill will visit LA Rams on Thursday, September 8, and ends with a game between the Denver Broncos vs Seattle Seahawks on Monday, September 12, 2022.
Thursday, September 8
| Matchup | Time (ET) | TV | Venue |
| Buffalo @ LA Rams | 8:20 PM | NBC | SoFi Stadium, Inglewood |
Sunday, September 11
| Matchup | Time (ET) | TV | Venue |
| New Orleans @ Atlanta | 1:00 PM | FOX | Mercedes-Benz Stadium, Atlanta |
| Cleveland @ Carolina | 1:00 PM | CBS | Soldier Field, Chicago |
| San Francisco @ Chicago | 1:00 PM | FOX | Paul Brown Stadium, Cincinnati |
| Pittsburgh @ Cincinnati | 1:00 PM | CBS | Ford Field, Detroit |
| Philadelphia @ Detroit | 1:00 PM | FOX | Hard Rock Stadium, Miami Gardens |
| Indianapolis @ Houston | 1:00 PM | CBS | MetLife Stadium, East Rutherford |
| New England @ Miami | 1:00 PM | CBS | FedExField, Landover |
| Baltimore @ NY Jets | 1:00 PM | CBS | Bank of America Stadium, Charlotte |
| Jacksonville @ Washington | 1:00 PM | FOX | NRG Stadium, Houston |
| Kansas City @ Arizona | 4:25 PM | CBS | Nissan Stadium, Nashville |
| Las Vegas @ LA Chargers | 4:25 PM | CBS | U.S. Bank Stadium, Minneapolis |
| Green Bay @ Minnesota | 4:25 PM | FOX | State Farm Stadium, Glendale |
| NY Giants @ Tennessee | 4:25 PM | FOX | SoFi Stadium, Inglewood |
| Tampa Bay @ Dallas | 8:20 PM | NBC | AT&T Stadium, Arlington |
Monday, September 12
| Matchup | Time (ET) | TV | Venue |
| Denver @ Seattle | 8:15 PM | ESPN | Lumen Field, Seattle |