2022 NFL Preseason Week 1, Thursday, August 11
| Game | Time (ET) | TV | Scores |
| New England vs NY Giants | 7:00 PM | Local/NFLN | TBD |
| Baltimore vs Tennessee | 7:30 PM | Local | TBD |
2022 NFL Preseason Week 1, Friday, August 12
| Game | Time (ET) | TV | Scores |
| Detroit vs Atlanta | 6:00 PM | Local/NFLN | TBD |
| Jacksonville vs Cleveland | 7:00 PM | Local | TBD |
| Cincinnati vs Arizona | 7:30 PM | Local | TBD |
| Philadelphia vs NY Jets | 7:30 PM | Local | TBD |
| San Francisco vs Green Bay | 8:30 PM | Local/NFLN | TBD |
2022 NFL Preseason Week 1, Saturday, August 13
| Game | Time (ET) | TV | Scores |
| Washington vs Carolina | 1:00 PM | Local | TBD |
| Chicago vs Kansas City | 1:00 PM | Local/NFLN | TBD |
| Buffalo vs Indianapolis | 4:00 PM | Local/NFLN | TBD |
| Pittsburgh vs Seattle | 7:00 PM | Local/NFLN | TBD |
| Tampa Bay vs Miami | 7:30 PM | Local | TBD |
| Houston vs New Orleans | 8:00 PM | Local | TBD |
| Denver vs Dallas | 9:00 PM | Local/NFLN | TBD |
| LA Chargers vs LA Rams | 10:00 PM | Local | TBD |
2022 NFL Preseason Week 1, Sunday, August 14
| Game | Time (ET) | TV | Scores |
| Las Vegas vs Minnesota | 4:25 PM | Local/NFLN | TBD |