NFL Week 12 Picks & Predictions 2025

Week 12 of the NFL season arrives with major playoff implications and a fresh set of compelling matchups. Several contenders look to strengthen their position, while struggling teams fight to keep their seasons alive. Using the latest Yahoo odds, we break down every matchup with clear picks, score predictions, and insight into why each team holds the edge. From key divisional showdowns to must-win games for fringe playoff hopefuls, Week 12 delivers plenty of drama – and we’re here to guide you through all of it.

Buffalo Bills (7-3) at Houston Texans (5-5)

• Odds: BUF -6 | O/U: 43.5
• Pick: Bills -6
• Prediction: Buffalo continues to roll behind Josh Allen’s explosive offense. Houston is competitive, but their defense won’t hold for four quarters.
• Score: Bills 27, Texans 20

New York Jets (2-8) at Baltimore Ravens (5-5)

• Odds: BAL -13.5 | O/U: 44.5
• Pick: Ravens -13.5
• Prediction: The Jets offense can’t keep up. Ravens defense + Lamar at home equals a blowout.
• Score: Ravens 31, Jets 13

Indianapolis Colts (8-2) at Kansas City Chiefs (5-5)

• Odds: KC -3.5 | O/U: 50.5
• Pick: Chiefs -3.5
• Prediction: Must-win spot for Kansas City. Mahomes outduels a tough Colts team in a high-scoring game.
• Score: Chiefs 28, Colts 24

Seattle Seahawks (7-3) at Tennessee Titans (1-9)

• Odds: SEA -13.5 | O/U: 40.5
• Pick: Seahawks -13.5
• Prediction: Tennessee can’t score. Seattle’s defense will dominate a bottom-ranked Titans offense.
• Score: Seahawks 24, Titans 6

Minnesota Vikings (4-6) at Green Bay Packers (6-3-1)

• Odds: GB -6.5 | O/U: 41
• Pick: Packers -6.5
• Prediction: Green Bay at home with the better defense and QB play. Minnesota too inconsistent.
• Score: Packers 23, Vikings 16

New York Giants (2-9) at Detroit Lions (6-4)

• Odds: DET -10.5 | O/U: 50
• Pick: Lions -10.5
• Prediction: Giants can’t trade punches with Detroit’s offense. Goff and the Lions roll.
• Score: Lions 31, Giants 17

New England Patriots (9-2) at Cincinnati Bengals (3-7)

• Odds: NE -7 | O/U: 50
• Pick: Patriots -7
• Prediction: Bengals defense won’t slow down New England’s balanced attack.
• Score: Patriots 30, Bengals 20

Pittsburgh Steelers (6-4) at Chicago Bears (7-3)

• Odds: CHI -2.5 | O/U: 45.5
• Pick: Bears -2.5
• Prediction: At home, Chicago’s defense makes the difference. Steelers offense still inconsistent.
• Score: Bears 24, Steelers 20

Jacksonville Jaguars (6-4) at Arizona Cardinals (3-7)

• Odds: JAX -3 | O/U: 47.5
• Pick: Jaguars -3
• Prediction: Jaguars’ offense should be too much for Arizona. Lawrence outplays Murray.
• Score: Jaguars 27, Cardinals 21

Cleveland Browns (2-8) at Las Vegas Raiders (2-8)

• Odds: LV -4 | O/U: 36
• Pick: Raiders -4
• Prediction: Low-scoring game but Vegas has more stability at QB and moves the ball better.
• Score: Raiders 17, Browns 13

Atlanta Falcons (3-7) at New Orleans Saints (2-8)

• Odds: NO -1.5 | O/U: 39.5
• Pick: Falcons +1.5 (Upset)
• Prediction: Falcons’ run game + more explosive playmakers give them the edge in a tight game.
• Score: Falcons 20, Saints 17

Philadelphia Eagles (8-2) at Dallas Cowboys (4-5-1)

• Odds: PHI -3.5 | O/U: 47.5
• Pick: Eagles -3.5
• Prediction: Eagles’ pass rush overwhelms Dallas. Hurts controls the tempo.
• Score: Eagles 27, Cowboys 21

Tampa Bay Buccaneers (6-4) at Los Angeles Rams (8-2)

• Odds: LAR -6.5 | O/U: 49.5
• Pick: Rams -6.5
• Prediction: Too much Stafford + Kupp + Rams defense at home.
• Score: Rams 30, Bucs 23

Carolina Panthers (6-5) at San Francisco 49ers (7-4)

• Odds: SF -7 | O/U: 49
• Pick: 49ers -7
• Prediction: Niners defense clamps down. McCaffrey scores vs former team.
• Score: 49ers 28, Panthers 20