| Rank | RBs | Team | Year | Game | att | rush yds | ypc | rush TD | rec | rec yds | rec TD | fumbles lost |
| 1 | Miles Sanders | Panthers | 5 | 17 | 259 | 1269 | 4.9 | 11 | 20 | 78 | 0 | 2 |
| 2 | David Montgomery | Lions | 5 | 16 | 201 | 801 | 4 | 5 | 34 | 316 | 1 | 2 |
| 3 | Jamaal Williams | Saints | 7 | 17 | 262 | 1066 | 4.1 | 17 | 12 | 73 | 0 | 2 |
| 4 | Samaje Perine | Broncos | 7 | 16 | 95 | 394 | 4.1 | 2 | 38 | 284 | 4 | 0 |
| 5 | Devin Singletary | Texans | 5 | 16 | 177 | 819 | 4.6 | 5 | 38 | 280 | 1 | 3 |
| 6 | James Robinson | Patriots | 4 | 11 | 110 | 425 | 3.9 | 3 | 11 | 51 | 2 | 0 |
| 7 | D’Onta Foreman | Bears | 7 | 17 | 203 | 914 | 4.5 | 5 | 5 | 26 | 0 | 0 |
| 8 | Damien Harris | Bills | 5 | 11 | 106 | 462 | 4.4 | 3 | 17 | 57 | 0 | 0 |
| 9 | Rashaad Penny | Eagles | 6 | 5 | 97 | 346 | 6.1 | 2 | 4 | 16 | 0 | 0 |
| 10 | D’Ernest Johnson | Jaguars | 5 | 15 | 4 | 17 | 4.3 | 0 | 3 | 7 | 0 | 0 |
| 11 | Ronald Jones | Cowboys | 6 | 6 | 17 | 70 | 4.1 | 1 | 1 | 22 | 0 | 0 |
| 12 | Chase Edmonds | Buccaneers | 6 | 13 | 68 | 245 | 3.6 | 2 | 16 | 157 | 1 | 0 |