| Rank | RBs | Team | Year | Game | att | rush yds | ypc | rush TD | rec | rec yds | rec TD | fumbles lost |
| 1 | Christian McCaffrey | 49ers | 7 | 13 | 226 | 1,177 | 5.2 | 12 | 52 | 437 | 5 | 2 |
| 2 | Raheem Mostert | Dolphins | 9 | 13 | 183 | 924 | 5 | 16 | 22 | 170 | 2 | 1 |
| 3 | Derrick Henry | Titans | 8 | 13 | 214 | 875 | 4.1 | 10 | 23 | 202 | 0 | 0 |
| 4 | Kyren Williams | Rams | 2 | 9 | 159 | 801 | 5 | 7 | 25 | 189 | 3 | 0 |
| 5 | David Montgomery | Lions | 5 | 10 | 161 | 770 | 4.8 | 10 | 12 | 106 | 0 | 1 |
| 6 | Travis Etienne | Jaguars | 3 | 13 | 219 | 806 | 3.7 | 9 | 44 | 383 | 1 | 0 |
| 7 | James Cook | Bills | 2 | 13 | 163 | 789 | 4.8 | 1 | 38 | 391 | 3 | 1 |
| 8 | Saquon Barkley | Giants | 6 | 10 | 185 | 783 | 4.2 | 3 | 31 | 183 | 4 | 2 |
| 9 | Josh Jacobs | Raiders | 5 | 13 | 233 | 805 | 3.5 | 6 | 37 | 296 | 0 | 1 |
| 10 | D’Andre Swift | Eagles | 4 | 13 | 178 | 822 | 4.6 | 4 | 36 | 208 | 1 | 1 |
| 11 | Bijan Robinson | Falcons | Rookie | 13 | 169 | 790 | 4.7 | 4 | 40 | 320 | 3 | 2 |
| 12 | Tony Pollard | Cowboys | 5 | 13 | 196 | 796 | 4.1 | 5 | 49 | 285 | 0 | 1 |
| 13 | Isiah Pacheco | Chiefs | 2 | 12 | 176 | 779 | 4.4 | 6 | 33 | 209 | 1 | 0 |
| 14 | De’Von Achane | Dolphins | Rookie | 7 | 63 | 581 | 9.2 | 7 | 18 | 125 | 2 | 1 |
| 15 | Jahmyr Gibbs | Lions | Rookie | 11 | 128 | 692 | 5.4 | 6 | 45 | 288 | 0 | 0 |