The Buffalo Bills and San Francisco 49ers results’ all-time regular season and playoff records in National Football League history. Here we have listed how many head-to-head fights they have, win, lose, tie, and postponed records with points and more you need to know.
What is Bills vs 49ers record?
Both teams have played each other 13 times so far, where the Bills win 7 games and the 49ers win 6 games.
Buffalo Bills leading the all-time series 7-6-0
| When | Where | Results |
| 12/07/2020 | Buffalo Bills at San Francisco 49ers | 34-24 (Bills) |
| 10/16/2016 | San Francisco 49ers at Buffalo Bills | 16-45 (Bills) |
| 10/07/2012 | Buffalo Bills at San Francisco 49ers | 3-45 (49ers) |
| 11/30/2008 | San Francisco 49ers at Buffalo Bills | 10-3 (49ers) |
| 12/26/2004 | Buffalo Bills at San Francisco 49ers | 41-7 (Bills) |
| 12/02/2001 | Buffalo Bills at San Francisco 49ers | 0-35 (49ers) |
| 10/4/1998 | San Francisco 49ers at Buffalo Bills | 21-26 (Bills) |
| 12/03/1995 | Buffalo Bills at San Francisco 49ers | 17-27 (49ers) |
| 09/13/1992 | Buffalo Bills at San Francisco 49ers | 34-31 (Bills) |
| 12/17/1989 | Buffalo Bills at San Francisco 49ers | 10-21 (49ers) |
| 12/11/1983 | San Francisco 49ers at Buffalo Bills | 23-10 (49ers) |
| 12/21/1980 | Buffalo Bills at San Francisco 49ers | 18-13 (Bills) |
| 09/24/1972 | San Francisco 49ers at Buffalo Bills | 20-27 (Bills) |