| Player Name | Jersey No | Pos | HT | WT | Age | Exp | College |
| Nasir Adderley | 24 | S | 6-0 | 206 | 25 | 4 | Delaware |
| Keenan Allen | 13 | WR | 6-2 | 211 | 30 | 10 | California |
| Joey Bosa | 97 | OLB | 6-5 | 280 | 27 | 7 | Ohio State |
| Bryce Callahan | 23 | CB | 5-9 | 188 | 30 | 8 | Rice |
| DeAndre Carter | 82 | WR | 5-8 | 190 | 29 | 5 | Sacramento State |
| Will Clapp | 76 | C/G | 6-5 | 311 | 26 | 5 | Louisiana State |
| Chase Daniel | 4 | QB | 6-0 | 229 | 35 | 13 | Missouri |
| Michael Davis | 43 | CB | 6-2 | 196 | 27 | 6 | Brigham Young |
| Austin Ekeler | 30 | RB | 5-10 | 200 | 27 | 6 | Western State Colorado |
| Gerald Everett | 7 | TE | 6-3 | 240 | 28 | 6 | South Alabama |
| Breiden Fehoko | 96 | DL | 6-3 | 300 | 25 | 2 | Louisiana State |
| Matt Feiler | 71 | G | 6-6 | 330 | 30 | 6 | Bloomsburg |
| Morgan Fox | 56 | DL | 6-3 | 275 | 27 | 6 | Colorado State-Pueblo |
| Alohi Gilman | 32 | S | 5-10 | 201 | 24 | 3 | Notre Dame |
| Jalen Guyton | 15 | WR | 6-1 | 212 | 25 | 3 | North Texas |
| Josh Harris | 47 | LS | 6-1 | 224 | 33 | 11 | Auburn |
| Justin Herbert | 10 | QB | 6-6 | 236 | 24 | 3 | Oregon |
| Dustin Hopkins | 6 | K | 6-2 | 193 | 31 | 9 | Florida State |
| Zander Horvath | 45 | FB | 6-3 | 230 | 23 | R | Purdue |
| J.C. Jackson | 27 | CB | 6-1 | 198 | 26 | 5 | Maryland |
| Brenden Jaimes | 64 | G/T | 6-5 | 300 | 23 | 2 | Nebraska |
| Derwin James Jr. | 3 | S | 6-2 | 215 | 26 | 5 | Florida State |
| Austin Johnson | 98 | DL | 6-4 | 314 | 28 | 7 | Penn State |
| Zion Johnson | 77 | G | 6-3 | 316 | 22 | R | Boston College |
| Sebastian Joseph-Day | 69 | DL | 6-4 | 310 | 27 | 5 | Rutgers |
| Joshua Kelley | 25 | RB | 5-11 | 212 | 24 | 3 | UCLA |
| Deane Leonard | 33 | DB | 6-0 | 195 | 22 | R | Mississippi |
| Corey Linsley | 63 | C | 6-3 | 301 | 31 | 9 | Ohio State |
| Khalil Mack | 52 | OLB | 6-3 | 269 | 31 | 9 | Buffalo |
| Tre’ McKitty | 88 | TE | 6-4 | 246 | 23 | 2 | Georgia |
| Kenneth Murray Jr. | 9 | LB | 6-2 | 241 | 23 | 3 | Oklahoma |
| Nick Niemann | 31 | LB | 6-3 | 244 | 24 | 2 | Iowa |
| Storm Norton | 74 | T | 6-7 | 317 | 28 | 3 | Toledo |
| Amen Ogbongbemiga | 57 | LB | 6-0 | 231 | 24 | 2 | Oklahoma State |
| Otito Ogbonnia | 93 | DL | 6-4 | 320 | 22 | R | UCLA |
| Joshua Palmer | 5 | WR | 6-1 | 210 | 22 | 2 | Tennessee |
| Donald Parham Jr. | 89 | TE | 6-8 | 237 | 25 | 3 | Stetson |
| Trey Pipkins III | 79 | T | 6-6 | 307 | 26 | 4 | Sioux Falls |
| Troy Reeder | 42 | LB | 6-3 | 245 | 27 | 4 | Delaware |
| Larry Rountree III | 34 | RB | 5-10 | 211 | 23 | 2 | Missouri |
| Chris Rumph II | 94 | OLB | 6-2 | 244 | 23 | 2 | Duke |
| Jamaree Salyer | 68 | G | 6-4 | 325 | 22 | R | Georgia |
| Asante Samuel Jr. | 26 | CB | 5-10 | 180 | 22 | 2 | Florida State |
| JK Scott | 16 | P | 6-5 | 208 | 26 | 4 | Alabama |
| Rashawn Slater | 70 | T | 6-4 | 315 | 23 | 2 | Northwestern |
| Isaiah Spiller | 28 | RB | 6-1 | 215 | 21 | R | Texas A&M |
| Easton Stick | 2 | QB | 6-1 | 224 | 26 | 4 | North Dakota State |
| Ja’Sir Taylor | 36 | DB | 5-10 | 185 | 23 | R | Wake Forest |
| Jerry Tillery | 99 | DL | 6-6 | 295 | 25 | 4 | Notre Dame |
| Drue Tranquill | 49 | LB | 6-2 | 234 | 27 | 4 | Notre Dame |
| Kyle Van Noy | 8 | LB | 6-3 | 250 | 31 | 9 | Brigham Young |
| Mike Williams | 81 | WR | 6-4 | 218 | 27 | 6 | Clemson |
| JT Woods | 22 | S | 6-2 | 193 | 22 | R | Baylor |
| Tevaughn Campbell | 20 | CB | 6-0 | 200 | 29 | 3 | Regina |
| Damon Lloyd | 53 | LB | 6-0 | 235 | 24 | 2 | Indiana (Pa.) |
| Forrest Merrill | 91 | DL | 6-0 | 322 | 26 | 1 | Arkansas State |
| Andrew Trainer | 62 | T | 6-7 | 320 | 24 | R | William & Mary |
| Isaac Weaver | 60 | C | 6-6 | 310 | 24 | R | Old Dominion |
| Stone Smartt | 48 | TE | 6-4 | 226 | 23 | R | Old Dominion |