| Opponent | Date | Time | TV | Venues |
| vs Duquesne Dukes | Sep. 3 | 2:00 PM | ESPN+ | Stambaugh Stadium |
| vs Dayton Flyers | Sep. 10 | 2:00 PM | TBA | Stambaugh Stadium |
| @ Kentucky Wildcats | Sep. 17 | 12:00 PM | SECN | Kroger Field |
| @ North Dakota State Bison | Oct. 1 | 2:00 PM | ABC ND/ESPN+ | Fargodome |
| vs North Dakota Fighting Hawks | Oct. 8 | 6:00 PM | TBA | Stambaugh Stadium |
| vs Indiana State Sycamores | Oct. 15 | 2:00 PM | TBA | Stambaugh Stadium |
| @ Western Illinois Leathernecks | Oct. 22 | TBA | TBA | Hanson Field |
| vs South Dakota Coyotes | Oct. 29 | 2:00 PM | TBA | Stambaugh Stadium |
| @ Illinois State Redbirds | Nov. 5 | 3:00 PM | MSN | Hancock Stadium |
| @ Missouri State Bears | Nov. 12 | TBA | TBA | Robert W. Plaster Stadium |
| vs Southern Illinois Salukis | Nov. 19 | 12:00 PM | ESPN3/+ | Stambaugh Stadium |