| Opponent | Date | Time (ET) | TV | Venues |
| @ Michigan State Spartans | Sep. 2 | 7:00 PM | ESPN | Spartan Stadium |
| @ Ball State Cardinals | Sep. 10 | 2:00 PM | ESPN+ | Scheumann Stadium |
| vs Pitt Panthers | Sep. 17 | 7:30 PM | ESPNU | Waldo Stadium |
| @ San Jose State Spartans | Sep. 24 | 10:30 PM | CBSSN | CEFCU Stadium |
| vs New Hampshire Wildcats | Oct. 1 | TBA | TBA | Waldo Stadium |
| vs Eastern Michigan Eagles | Oct. 8 | TBA | TBA | Waldo Stadium |
| vs Ohio Bobcats (HC) | Oct. 15 | 3:30 PM | TBA | Waldo Stadium |
| @ Miami (Ohio) RedHawks | Oct. 22 | TBA | TBA | Yager Stadium |
| @ Bowling Green Falcons | Nov. 2 | 7:00 PM | ESPN2/ESPNU | Doyt Perry Stadium |
| vs NIU Huskies | Nov. 9 | 7:00 PM | ESPN2/U/CBSSN | Waldo Stadium |
| @ Central Michigan Chippewas | Nov. 16 | 6/7/8 PM | ESPN2/U/CBSSN | Kelly/Shorts Stadium |
| vs Toledo Rockets | Nov. 25 | 12:00 PM | ESPNU/CBSSN | Waldo Stadium |
| vs MAC Championship | Dec. 3 | 12:00 PM | ESPN | Ford Field |