| Opponent | Date | Time (ET) | TV | Venues |
| @ Pitt Panthers | Sep. 1 | 7:00 PM | ESPN | Heinz Field |
| vs Kansas Jayhawks | Sep. 10 | 6:00pm ET | ESPN+ | Mountaineer Field |
| vs Towson Tigers | Sep. 17 | 1:00 PM | ESPN+ | Mountaineer Field |
| @ Virginia Tech Hokies | Sep. 22 | 7:30 PM | ESPN | Lane Stadium |
| @ Texas Longhorns | Oct. 1 | TBA | TBA | DKR-Texas Memorial Stadium |
| vs Baylor Bears | Oct. 13 | 7:00 PM | FS1 | Mountaineer Field |
| @ Texas Tech Red Raiders | Oct. 22 | TBA | TBA | Jones AT&T Stadium |
| vs TCU Horned Frogs (HC) | Oct. 29 | TBA | TBA | Mountaineer Field |
| @ Iowa State Cyclones | Nov. 5 | TBA | TBA | Jack Trice Stadium |
| vs Oklahoma Sooners | Nov. 12 | TBA | TBA | Mountaineer Field |
| vs Kansas State Wildcats | Nov. 19 | TBA | TBA | Mountaineer Field |
| @ Oklahoma State Cowboys | Nov. 26 | TBA | ESPN network | Boone Pickens Stadium |
| vs Big 12 Championship | Dec. 3 | TBA | ABC | AT&T Stadium |