| Opponent | Date | Time (ET) | TV | Venues |
| vs Kent State Golden Flashes | Sep. 3 | 10:30pm ET | FS1 | Husky Stadium |
| vs Portland State Vikings | Sep. 10 | 4:00pm ET | P12 Now/P12W | Husky Stadium |
| vs Michigan State Spartans | Sep. 17 | 7:30pm ET | ABC | Husky Stadium |
| vs Stanford Cardinal | Sep. 24 | TBA | TBA | Husky Stadium |
| @ UCLA Bruins | Sep. 30 | 10:30pm ET | ESPN | Rose Bowl Stadium |
| @ Arizona State Sun Devils | Oct. 8 | TBA | TBA | Sun Devil Stadium |
| vs Arizona Wildcats | Oct. 15 | TBA | TBA | Husky Stadium |
| @ California Golden Bears | Oct. 22 | TBA | TBA | Cal Memorial Stadium |
| vs Oregon State Beavers | Nov. 4 | 10:30pm ET | ESPN2 | Husky Stadium |
| @ Oregon Ducks | Nov. 12 | TBA | TBA | Autzen Stadium |
| vs Colorado Buffaloes | Nov. 19 | TBA | TBA | Husky Stadium |
| @ Washington State Cougars | Nov. 26 | TBA | TBA | Martin Stadium |
| vs Pac-12 Championship | Dec. 2 | 8:00pm ET | FOX | Allegiant Stadium |