| Opponent | Date | Time (ET) | TV | Venues |
| @ Hawaii Rainbow Warriors | Aug. 27 | 10:30 PM | CBSSN | Ching Complex |
| vs Elon Phoenix | Sep. 3 | 7:00 PM | SECN+/ESPN+ | Vanderbilt Stadium |
| vs Wake Forest Demon Deacons | Sep. 10 | 12:00 PM | SECN | Vanderbilt Stadium |
| @ NIU Huskies | Sep. 17 | 3:30 PM | CBSSN | Huskie Stadium |
| @ Alabama Crimson Tide | Sep. 24 | TBA | TBA | Bryant-Denny Stadium |
| vs Ole Miss Rebels | Oct. 8 | TBA | TBA | Vanderbilt Stadium |
| @ Georgia Bulldogs | Oct. 15 | TBA | TBA | Sanford Stadium |
| @ Missouri Tigers | Oct. 22 | TBA | TBA | Faurot Field |
| vs South Carolina Gamecocks | Nov. 5 | TBA | TBA | Vanderbilt Stadium |
| @ Kentucky Wildcats | Nov. 12 | TBA | TBA | Kroger Field |
| vs Florida Gators | Nov. 19 | TBA | TBA | Vanderbilt Stadium |
| vs Tennessee Volunteers | Nov. 26 | TBA | TBA | Vanderbilt Stadium |
| vs SEC Championship | Dec. 3 | 4:00 PM | CBS | Mercedes-Benz Stadium |