| Opponent | Date | Time (ET) | TV | Venues |
| vs Houston Cougars | Sep. 3 | 3:30 PM | CBSSN | Alamodome |
| @ Army Black Knights | Sep. 10 | 12:00 PM | CBSSN | Michie Stadium |
| @ Texas Longhorns | Sep. 17 | 8:00 PM | LHN | DKR-Texas Memorial Stadium |
| vs Texas Southern Tigers | Sep. 24 | 3:30 PM | Stadium | Alamodome |
| @ Middle Tennessee Blue Raiders | Sep. 30 | 7:30 PM | CBSSN | Johnny “Red” Floyd Stadium |
| vs WKU Hilltoppers | Oct. 8 | 6:00 PM | ESPN network | Alamodome |
| @ FIU Panthers | Oct. 14 | 8:00 PM | CBSSN | Riccardo Silva Stadium |
| vs North Texas Mean Green | Oct. 22 | 3:30 PM | Stadium | Alamodome |
| @ UAB Blazers | Nov. 5 | 3:30 PM | Stadium | Protective Stadium |
| vs Louisiana Tech Bulldogs | Nov. 12 | 3:30 PM | ESPN network | Alamodome |
| @ Rice Owls | Nov. 19 | 1:00 PM | ESPN network | Rice Stadium |
| vs UTEP Miners | Nov. 26 | 3:30 PM | Stadium | Alamodome |
| vs C-USA Championship | Dec. 2 | 8:00 PM | CBSSN | TBD |