| Opponent | Date | Time (ET) | TV | Venues |
| vs BYU Cougars | Sep. 3 | 4:00 PM | ESPNU | Raymond James Stadium |
| vs Howard Bison | Sep. 10 | 7:00 PM | ESPN+ | Raymond James Stadium |
| @ Florida Gators | Sep. 17 | 7:30 PM | SECN | Ben Hill Griffin Stadium |
| @ Louisville Cardinals | Sep. 24 | TBA | TBA | Cardinal Stadium |
| vs East Carolina Pirates | Oct. 1 | TBA | TBA | Raymond James Stadium |
| @ Cincinnati Bearcats | Oct. 8 | TBA | TBA | Nippert Stadium |
| vs Tulane Green Wave (HC) | Oct. 15 | TBA | TBA | Raymond James Stadium |
| @ Houston Cougars | Oct. 29 | TBA | TBA | TDECU Stadium |
| @ Temple Owls | Nov. 5 | TBA | TBA | Lincoln Financial Field |
| vs SMU Mustangs | Nov. 12 | TBA | TBA | Raymond James Stadium |
| @ Tulsa Golden Hurricane | Nov. 18 | 9:00 PM | ESPN2 | H.A. Chapman Stadium |
| vs UCF Knights | Nov. 26 | TBA | TBA | Raymond James Stadium |
| vs American Championship | Dec. 3 | 4:00 PM | ABC | TBD |