| Opponent | Date | Time (ET) | TV | Venues |
| vs Rice Owls | Sep. 3 | 6:00 PM | P12N | LA Memorial Coliseum |
| @ Stanford Cardinal | Sep. 10 | 7:30 PM | ABC | Stanford Stadium |
| vs Fresno State Bulldogs | Sep. 17 | 10:30 PM | FOX | LA Memorial Coliseum |
| @ Oregon State Beavers | Sep. 24 | TBA | TBA | Reser Stadium |
| vs Arizona State Sun Devils | Oct. 1 | TBA | TBA | LA Memorial Coliseum |
| vs Washington State Cougars | Oct. 8 | TBA | TBA | LA Memorial Coliseum |
| @ Utah Utes | Oct. 15 | TBA | TBA | Rice-Eccles Stadium |
| @ Arizona Wildcats | Oct. 29 | TBA | TBA | Arizona Stadium |
| vs California Golden Bears | Nov. 5 | TBA | TBA | LA Memorial Coliseum |
| vs Colorado Buffaloes | Nov. 11 | 9:30 PM | FS1 | LA Memorial Coliseum |
| @ UCLA Bruins | Nov. 19 | TBA | TBA | Rose Bowl Stadium |
| vs Notre Dame Fighting Irish | Nov. 26 | TBA | TBA | LA Memorial Coliseum |
| vs Pac-12 Championship | Dec. 2 | 8:00 PM | FOX | Allegiant Stadium |