| Opponent | Date | Time (ET) | TV | Venues |
| vs Ball State Cardinals | Sep. 1 | 7:00 PM | SECN | Neyland Stadium |
| @ Pitt Panthers | Sep. 10 | 3:30 PM | ABC | Heinz Field |
| vs Akron Zips | Sep. 17 | 7:00 PM | SECN+/ESPN+ | Neyland Stadium |
| vs Florida Gators | Sep. 24 | TBA | TBA | Neyland Stadium |
| @ LSU Tigers | Oct. 8 | TBA | TBA | Tiger Stadium |
| vs Alabama Crimson Tide | Oct. 15 | TBA | TBA | Neyland Stadium |
| vs UT Martin Skyhawks (HC) | Oct. 22 | TBA | TBA | Neyland Stadium |
| vs Kentucky Wildcats | Oct. 29 | TBA | TBA | Neyland Stadium |
| @ Georgia Bulldogs | Nov. 5 | TBA | TBA | Sanford Stadium |
| vs Missouri Tigers | Nov. 12 | TBA | TBA | Neyland Stadium |
| @ South Carolina Gamecocks | Nov. 19 | TBA | TBA | Williams-Brice Stadium |
| @ Vanderbilt Commodores | Nov. 26 | TBA | TBA | Vanderbilt Stadium |
| vs SEC Championship | Dec. 3 | 4:00 PM | CBS | Mercedes-Benz Stadium |