| Opponent | Date | Time (ET) | TV | Venues |
| vs Louisville Cardinals | Sep. 3 | 8:00 PM | ACCN | JMA Wireless Dome, |
| @ UConn Huskies | Sep. 10 | 7:00 PM | CBSSN | Rentschler Field |
| vs Purdue Boilermakers | Sep. 17 | 12:00 PM | ESPN2 | JMA Wireless Dome |
| vs Virginia Cavaliers | Sep. 23 | 7:30 PM | ESPN | JMA Wireless Dome |
| vs Wagner Seahawks (HC) | Oct. 1 | TBA | TBA | JMA Wireless Dome |
| vs NC State Wolfpack | Oct. 15 | TBA | TBA | JMA Wireless Dome |
| @ Clemson Tigers | Oct. 22 | TBA | TBA | Memorial Stadium |
| vs Notre Dame Fighting Irish | Oct. 29 | TBA | TBA | JMA Wireless Dome |
| @ Pitt Panthers | Nov. 5 | TBA | TBA | Heinz Field |
| vs Florida State Seminoles | Nov. 12 | TBA | TBA | JMA Wireless Dome |
| @ Wake Forest Demon Deacons | Nov. 19 | TBA | TBA | Truist Field |
| @ Boston College Eagles | Nov. 26 | TBA | TBA | Alumni Stadium |
| vs ACC Championship | Dec. 3 | TBA | ABC | Bank of America Stadium |