San Francisco 49ers preseason schedule
| Opponent | Date | Time (ET) | TV |
| vs Green Bay Packers | Aug. 12 | 8:30 PM | NFLN |
| @ Minnesota Vikings | Aug. 20 | 7:00 PM | NFLN |
| @ Houston Texans | Aug. 25 | 8:15 PM | Prime Video |
San Francisco 49ers regular season schedule
| Opponent | Date | Time | TV |
| @ Chicago | Sun, 11 Sep | 1:00 PM | FOX |
| vs Seattle | Sun, 18 Sep | 4:05 PM | FOX |
| @ Denver | Sun, 25 Sep | 8:20 PM | NBC |
| vs Los Angeles | Mon, 3 Oct | 8:15 PM | ESPN |
| @ Carolina | Sun, 9 Oct | 4:05 PM | CBS |
| @ Atlanta | Sun, 16 Oct | 1:00 PM | FOX |
| vs Kansas City | Sun, 23 Oct | 4:25 PM | FOX |
| @ Los Angeles | Sun, 30 Oct | 4:25 PM | FOX |
| vs Los Angeles | Sun, 13 Nov | 8:20 PM | NBC |
| vs Arizona | Mon, 21 Nov | 8:00 PM | ESPN |
| vs New Orleans | Sun, 27 Nov | 4:25 PM | FOX |
| vs Miami | Sun, 4 Dec | 4:05 PM | FOX |
| vs Tampa Bay | Sun, 11 Dec | 4:25 PM | FOX |
| @ Seattle | Thu, 15 Dec | 8:15 PM | Prime Video |
| vs Washington | Sat, 24 Dec | 4:05 PM | CBS |
| @ Las Vegas | Sat, 1 Jan | 4:05 PM | FOX |
| vs Arizona | Sat, 8 Jan | TBD | TBD |