| Opponent | Date | Time (ET) | TV | Venues |
| @ Boston College Eagles | Sep. 3 | 12:00 PM | ACCN | Alumni Stadium |
| vs Wagner Seahawks | Sep. 10 | 4:00 PM | BTN | SHI Stadium |
| @ Temple Owls | Sep. 17 | 2:00 PM | ESPN+ | Lincoln Financial Field |
| vs Iowa Hawkeyes | Sep. 24 | TBA | TBA | SHI Stadium |
| @ Ohio State Buckeyes | Oct. 1 | 3:30 PM | TBA | Ohio Stadium |
| vs Nebraska Cornhuskers | Oct. 7 | 7:00 PM | FS1 | SHI Stadium |
| vs Indiana Hoosiers (HC) | Oct. 22 | 12:00 PM | TBA | SHI Stadium |
| @ Minnesota Golden Gophers | Oct. 29 | TBA | TBA | Huntington Bank Stadium |
| vs Michigan Wolverines | Nov. 5 | TBA | TBA | SHI Stadium |
| @ Michigan State Spartans | Nov. 12 | TBA | TBA | Spartan Stadium |
| vs Penn State Nittany Lions | Nov. 19 | TBA | TBA | SHI Stadium |
| @ Maryland Terrapins | Nov. 26 | TBA | TBA | Maryland Stadium |
| vs Big Ten Championship | Dec. 3 | 8:00 PM | FOX | Lucas Oil Stadium |