| Opponent | Date | Time (ET) | TV | Venues |
| @ USC Trojans | Sep. 3 | 6:00 PM | P12N | LA Memorial Coliseum |
| vs McNeese Cowboys | Sep. 10 | 7:30 PM | ESPN3 | Rice Stadium |
| vs Louisiana Ragin’ Cajuns | Sep. 17 | 7:30 PM | ESPN+ | Rice Stadium |
| @ Houston Cougars | Sep. 24 | TBA | TBA | TDECU Stadium |
| vs UAB Blazers | Oct. 1 | 7:30 PM | ESPN network | Rice Stadium |
| @ Florida Atlantic Owls | Oct. 15 | 6:00 PM | ESPN network | FAU Stadium |
| @ Louisiana Tech Bulldogs | Oct. 22 | 3:00 PM | ESPN network | Joe Aillet Stadium |
| vs Charlotte 49ers (HC) | Oct. 29 | 2:00 PM | ESPN network | Rice Stadium |
| vs UTEP Miners | Nov. 3 | 7:00 PM | CBSSN | Rice Stadium |
| @ WKU Hilltoppers | Nov. 12 | 2:00 PM | ESPN network | Houchens-Smith Stadium, |
| vs UTSA Roadrunners | Nov. 19 | 1:00 PM | ESPN network | Rice Stadium |
| @ North Texas Mean Green | Nov. 26 | 2:00 PM | ESPN network | Apogee Stadium |
| vs C-USA Championship | Dec. 2 | 8:00 PM | CBSSN | TBD |