| Opponent | Date | Time (ET) | TV | Venues |
| vs Penn State Nittany Lions | Sep. 1 | 8:00 PM | FOX | Ross-Ade Stadium |
| vs Indiana State Sycamores | Sep. 10 | 4:00 PM | BTN | Ross-Ade Stadium |
| @ Syracuse Orange | Sep. 17 | 12:00 PM | ESPN2 | JMA Wireless Dome |
| vs Florida Atlantic Owls (HC) | Sep. 24 | 7:30 PM | BTN | Ross-Ade Stadium |
| @ Minnesota Golden Gophers | Oct. 1 | 12:00 PM | TBA | Huntington Bank Stadium |
| @ Maryland Terrapins | Oct. 8 | TBA | TBA | Maryland Stadium |
| vs Nebraska Cornhuskers | Oct. 15 | TBA | TBA | Ross-Ade Stadium |
| @ Wisconsin Badgers | Oct. 22 | 3:30 PM | TBA | Camp Randall Stadium |
| vs Iowa Hawkeyes | Nov. 5 | TBA | TBA | Ross-Ade Stadium |
| @ Illinois Fighting Illini | Nov. 12 | TBA | TBA | Memorial Stadium |
| vs Northwestern Wildcats | Nov. 19 | TBA | TBA | Ross-Ade Stadium |
| @ Indiana Hoosiers | Nov. 26 | TBA | TBA | Memorial Stadium |
| vs Big Ten Championship | Dec. 3 | 8:00 PM | FOX | Lucas Oil Stadium |