| Opponent | Date | Time (ET) | TV | Venues |
| vs UTEP Miners | Sep. 3 | 3:30 PM | FOX | Gaylord Family OK Mem. Stadium |
| vs Kent State Golden Flashes | Sep. 10 | 7:00 PM | ESPN+ | Gaylord Family OK Mem. Stadium |
| @ Nebraska Cornhuskers | Sep. 17 | 12:00 PM | FOX | Memorial Stadium |
| vs Kansas State Wildcats | Sep. 24 | TBA | TBA | Gaylord Family OK Mem. Stadium |
| @ TCU Horned Frogs | Oct. 1 | TBA | TBA | Amon G. Carter Stadium |
| vs Texas Longhorns | Oct. 8 | TBA | ABC | Cotton Bowl Stadium |
| vs Kansas Jayhawks | Oct. 15 | TBA | TBA | Gaylord Family OK Mem. Stadium |
| @ Iowa State Cyclones | Oct. 29 | TBA | FOX or FS1 | Jack Trice Stadium |
| vs Baylor Bears | Nov. 5 | TBA | TBA | Gaylord Family OK Mem. Stadium |
| @ West Virginia Mountaineers | Nov. 12 | TBA | TBA | Mountaineer Field |
| vs Oklahoma State Cowboys | Nov. 19 | TBA | TBA | Gaylord Family OK Mem. Stadium |
| @ Texas Tech Red Raiders | Nov. 26 | TBA | TBA | Jones AT&T Stadium |
| vs Big 12 Championship | Dec. 3 | TBA | ABC | AT&T Stadium |