| Opponent | Date | Time (ET) | TV | Venues |
| vs Notre Dame Fighting Irish | Sep. 3 | 7:30 PM | ABC | Ohio Stadium |
| vs Arkansas State Red Wolves | Sep. 10 | 12:00 PM | BTN | Ohio Stadium |
| vs Toledo Rockets | Sep. 17 | 7:00 PM | FOX | Ohio Stadium |
| vs Wisconsin Badgers | Sep. 24 | TBA | ABC | Ohio Stadium |
| vs Rutgers Scarlet Knights (HC) | Oct. 1 | 3:30 PM | TBA | Ohio Stadium |
| @ Michigan State Spartans | Oct. 8 | TBA | TBA | Spartan Stadium |
| vs Iowa Hawkeyes | Oct. 22 | TBA | TBA | Ohio Stadium |
| @ Penn State Nittany Lions | Oct. 29 | TBA | TBA | Beaver Stadium |
| @ Northwestern Wildcats | Nov. 5 | TBA | TBA | Ryan Field |
| vs Indiana Hoosiers | Nov. 12 | TBA | TBA | Ohio Stadium |
| @ Maryland Terrapins | Nov. 19 | TBA | TBA | Maryland Stadium |
| vs Michigan Wolverines | Nov. 26 | 12:00 PM | FOX | Ohio Stadium |
| vs Big Ten Championship | Dec. 3 | 8:00 PM | FOX | Lucas Oil Stadium |