| Opponent | Date | Time (ET) | TV | Venues |
| vs Florida Atlantic Owls | Sep. 3 | 6:00 PM | ESPN+ | Peden Stadium |
| @ Penn State Nittany Lions | Sep. 10 | 12:00 PM | ABC | Beaver Stadium |
| @ Iowa State Cyclones | Sep. 17 | 2:00 PM | ESPN+ | Jack Trice Stadium |
| vs Fordham Rams | Sep. 24 | TBA | TBA | Peden Stadium |
| @ Kent State Golden Flashes | Oct. 1 | 3:30 PM | TBA | Dix Stadium |
| vs Akron Zips (HC) | Oct. 8 | 2:00 PM | TBA | Peden Stadium |
| @ Western Michigan Broncos | Oct. 15 | 3:30 PM | TBA | Waldo Stadium |
| vs NIU Huskies | Oct. 22 | TBA | TBA | Peden Stadium |
| vs Buffalo Bulls | Nov. 1 | 7/7:30 PM | ESPN2/ESPNU | Peden Stadium |
| @ Miami (Ohio) RedHawks | Nov. 8 | 7/7:30 PM | ESPN2/U/CBSSN | Yager Stadium |
| @ Ball State Cardinals | Nov. 15 | 7:00 PM | ESPN2/ESPNU | Scheumann Stadium |
| vs Bowling Green Falcons | Nov. 22 | 7:00 PM | ESPNU/ESPN+ | Peden Stadium |
| vs MAC Championship | Dec. 3 | 12:00 PM | ESPN | Ford Field |