| Opponent | Date | Time (ET) | TV | Venues |
| @ Ohio State Buckeyes | Sep. 3 | 7:30 PM | ABC | Ohio Stadium |
| vs Marshall Thundering Herd | Sep. 10 | 2:30 PM | NBC | Notre Dame Stadium |
| vs California Golden Bears | Sep. 17 | 2:30 PM | NBC | Notre Dame Stadium |
| @ North Carolina Tar Heels | Sep. 24 | TBA | TBA | Kenan Memorial Stadium |
| vs BYU Cougars | Oct. 8 | 7:30 PM | NBC | Allegiant Stadium |
| vs Stanford Cardinal | Oct. 15 | 7:30 PM | NBC | Notre Dame Stadium |
| vs UNLV Rebels | Oct. 22 | 2:30 PM | NBC | Notre Dame Stadium |
| @ Syracuse Orange | Oct. 29 | TBA | TBA | JMA Wireless Dome |
| vs Clemson Tigers | Nov. 5 | 7:30 PM | NBC | Notre Dame Stadium |
| vs Navy Midshipmen | Nov. 12 | 12:00 PM | ABC or ESPN | M&T Bank Stadium |
| vs Boston College Eagles | Nov. 19 | 2:30 PM | NBC | Notre Dame Stadium |
| @ USC Trojans | Nov. 26 | TBA | TBA | LA Memorial Coliseum |