| Opponent | Date | Time (ET) | TV | Venues |
| vs Nebraska Cornhuskers | Aug. 27 | 12:30 PM | FOX | Aviva Stadium |
| vs Duke Blue Devils | Sep. 10 | 12:00 PM | FS1 | Ryan Field |
| vs Southern Illinois Salukis | Sep. 17 | 12:00 PM | BTN | Ryan Field |
| vs Miami (Ohio) RedHawks | Sep. 24 | TBA | BTN | Ryan Field |
| @ Penn State Nittany Lions | Oct. 1 | TBA | ESPN network | Beaver Stadium |
| vs Wisconsin Badgers (HC) | Oct. 8 | 3:30 or 4 PM | TBA | Ryan Field |
| @ Maryland Terrapins | Oct. 22 | 3:30 PM | TBA | Maryland Stadium |
| @ Iowa Hawkeyes | Oct. 29 | 3 or 3:30 PM | TBA | Kinnick Stadium |
| vs Ohio State Buckeyes | Nov. 5 | TBA | TBA | Ryan Field |
| @ Minnesota Golden Gophers | Nov. 12 | TBA | TBA | Huntington Bank Stadium |
| @ Purdue Boilermakers | Nov. 19 | TBA | TBA | Ross-Ade Stadium |
| vs Illinois Fighting Illini | Nov. 26 | TBA | TBA | Ryan Field |
| vs Big Ten Championship | Dec. 3 | 8:00 PM | FOX | Lucas Oil Stadium |