| Opponent | Date | Time (ET) | TV | Venues |
| vs Eastern Illinois Panthers | Sep. 1 | 8:00 PM | ESPN+ | Huskie Stadium |
| @ Tulsa Golden Hurricane | Sep. 10 | 7:00 PM | ESPN+ | H.A. Chapman Stadium |
| vs Vanderbilt Commodores | Sep. 17 | 3:30 PM | CBSSN | Huskie Stadium |
| @ Kentucky Wildcats | Sep. 24 | TBA | TBA | Kroger Field |
| @ Ball State Cardinals | Oct. 1 | TBA | TBA | Scheumann Stadium |
| vs Toledo Rockets (HC) | Oct. 8 | 3:30 PM | TBA | Huskie Stadium |
| @ Eastern Michigan Eagles | Oct. 15 | TBA | TBA | Rynearson Stadium |
| @ Ohio Bobcats | Oct. 22 | TBA | TBA | Peden Stadium |
| vs Central Michigan Chippewas | Nov. 2 | 7:00 PM | ESPN2/ESPNU | Huskie Stadium |
| @ Western Michigan Broncos | Nov. 9 | 7:00 PM | ESPN2/U/CBSSN | Waldo Stadium |
| vs Miami (Ohio) RedHawks | Nov. 16 | 6 or 7 PM | ESPN2/ESPNU | Huskie Stadium |
| vs Akron Zips | Nov. 26 | TBA | TBA | Huskie Stadium |
| vs MAC Championship | Dec. 3 | 12:00 PM | ESPN | Ford Field |