| Opponent | Date | Time (ET) | TV | Venues |
| vs Florida A&M Rattlers | Aug. 27 | 8:15 PM | ACCN | Kenan Memorial Stadium |
| @ Appalachian State Mountaineers | Sep. 3 | 12:00 PM | ESPNU | Kidd Brewer Stadium |
| @ Georgia State Panthers | Sep. 10 | 12:00 PM | ESPNU | Center Parc Stadium |
| vs Notre Dame Fighting Irish | Sep. 24 | TBA | TBA | Kenan Memorial Stadium |
| vs Virginia Tech Hokies | Oct. 1 | TBA | TBA | Kenan Memorial Stadium |
| @ Miami (FL) Hurricanes | Oct. 8 | TBA | TBA | Hard Rock Stadium |
| @ Duke Blue Devils | Oct. 15 | TBA | TBA | Wallace Wade Stadium |
| vs Pitt Panthers (HC) | Oct. 29 | TBA | TBA | Kenan Memorial Stadium |
| @ Virginia Cavaliers | Nov. 5 | TBA | TBA | Scott Stadium |
| @ Wake Forest Demon Deacons | Nov. 12 | TBA | TBA | Truist Field |
| vs Georgia Tech Yellow Jackets | Nov. 19 | TBA | TBA | Kenan Memorial Stadium |
| vs NC State Wolfpack | Nov. 25 | 12/1/3:30 PM | ABC or ESPN | Kenan Memorial Stadium |
| ACC Championship | Dec. 3 | TBA | ABC | Bank of America Stadium |