| Opponent | Date | Time (ET) | TV | Venues |
| vs NC Central Eagles | Sep. 3 | 7:30 PM | ESPN3 | Bank of America Stadium |
| @ North Dakota State Bison | Sep. 10 | 3:30 PM | ABC ND/ESPN+ | Fargodome |
| @ Duke Blue Devils | Sep. 17 | 6:00 PM | ACCNX/ESPN+ | Wallace Wade Stadium |
| vs SC State Bulldogs | Sep. 24 | 7:00 PM | TBA | Truist Stadium |
| vs Bryant Bulldogs | Oct. 1 | 7:00 PM | TBA | Truist Stadium |
| vs Bryant Bulldogs | Oct. 8 | 7:00 PM | TBA | Truist Stadium |
| vs Edward Waters Tigers | Oct. 15 | 1:00 PM | TBA | Truist Stadium |
| @ Robert Morris Colonials | Oct. 22 | 12:00 PM | TBA | Joe Walton Stadium |
| vs Campbell Camels (HC) | Oct. 29 | 1:00 PM | TBA | Truist Stadium |
| vs Norfolk State Spartans | Nov. 5 | 12:00 PM | TBA | Truist Stadium |
| vs Charleston Sou. Buccaneers | Nov. 12 | 12:00 PM | TBA | Truist Stadium |
| @ Gardner-Webb Runnin’ Bulldogs | Nov. 19 | 1:30 PM | TBA | Ernest W. Spangler Stadium |