| Opponent | Date | Time (ET) | TV | Venues |
| vs Northwestern Wildcats | Aug. 27 | 12:30 PM | FOX | Aviva Stadium |
| vs North Dakota Fighting Hawks | Sep. 3 | 3:30 PM | BTN | Memorial Stadium |
| vs Georgia Southern Eagles | Sep. 10 | 7:30 PM | FS1 | Memorial Stadium |
| vs Oklahoma Sooners | Sep. 17 | 12:00 PM | FOX | Memorial Stadium |
| vs Indiana Hoosiers (HC) | Oct. 1 | 7 or 7:30 PM | TBA | Memorial Stadium |
| @ Rutgers Scarlet Knights | Oct. 7 | 7:00 PM | FS1 | SHI Stadium |
| @ Purdue Boilermakers | Oct. 15 | TBA | TBA | Ross-Ade Stadium |
| vs Illinois Fighting Illini | Oct. 29 | TBA | TBA | Memorial Stadium |
| vs Minnesota Golden Gophers | Nov. 5 | TBA | TBA | Memorial Stadium |
| @ Michigan Wolverines | Nov. 12 | TBA | TBA | Michigan Stadium |
| vs Wisconsin Badgers | Nov. 19 | TBA | TBA | Memorial Stadium |
| @ Iowa Hawkeyes | Nov. 25 | 4:00 PM | BTN | Kinnick Stadium |
| vs Big Ten Championship | Dec. 3 | 8:00 PM | FOX | Lucas Oil Stadium |