| Opponent | Date | Time (ET) | TV | Venues |
| vs New Mexico State Aggies | Sep. 1 | 9:00 PM | BTN | Huntington Bank Stadium |
| vs Western Illinois Leathernecks | Sep. 10 | 12:00 PM | BTN | Huntington Bank Stadium |
| vs Colorado Buffaloes | Sep. 17 | 3:30 PM | ESPN2 | Huntington Bank Stadium |
| @ Michigan State Spartans | Sep. 24 | TBA | TBA | Spartan Stadium |
| vs Purdue Boilermakers (HC) | Oct. 1 | 12:00 PM | TBA | Huntington Bank Stadium |
| @ Illinois Fighting Illini | Oct. 15 | 12:00 PM | TBA | Memorial Stadium |
| @ Penn State Nittany Lions | Oct. 22 | 7:30 PM | TBA | Beaver Stadium |
| vs Rutgers Scarlet Knights | Oct. 29 | TBA | TBA | Huntington Bank Stadium |
| @ Nebraska Cornhuskers | Nov. 5 | TBA | TBA | Memorial Stadium |
| vs Northwestern Wildcats | Nov. 12 | TBA | TBA | Huntington Bank Stadium |
| vs Iowa Hawkeyes | Nov. 19 | TBA | TBA | Huntington Bank Stadium |
| @ Wisconsin Badgers | Nov. 26 | TBA | TBA | Camp Randall Stadium |
| vs Big Ten Championship | Dec. 3 | 8:00 PM | FOX | Lucas Oil Stadium |