| Opponent | Date | Time (ET) | TV | Venues |
| vs Western Michigan Broncos | Sep. 2 | 7:00 PM | ESPN | Spartan Stadium |
| vs Akron Zips | Sep. 10 | 4:00 PM | BTN | Spartan Stadium |
| @ Washington Huskies | Sep. 17 | 7:30 PM | ABC | Husky Stadium |
| vs Minnesota Golden Gophers | Sep. 24 | TBA | TBA | Spartan Stadium |
| @ Maryland Terrapins | Oct. 1 | TBA | TBA | Maryland Stadium |
| vs Ohio State Buckeyes | Oct. 8 | TBA | TBA | Spartan Stadium |
| vs Wisconsin Badgers (HC) | Oct. 15 | 3:30 PM | TBA | Spartan Stadium |
| @ Michigan Wolverines | Oct. 29 | TBA | TBA | Michigan Stadium |
| @ Illinois Fighting Illini | Nov. 5 | TBA | TBA | Memorial Stadium |
| vs Rutgers Scarlet Knights | Nov. 12 | TBA | TBA | Spartan Stadium |
| vs Indiana Hoosiers | Nov. 19 | TBA | TBA | Spartan Stadium |
| @ Penn State Nittany Lions | Nov. 26 | TBA | TBA | Beaver Stadium |
| vs Big Ten Championship | Dec. 3 | 8:00 PM | FOX | Lucas Oil Stadium |