| Opponent | Date | Time (ET) | TV | Venues |
| @ Kentucky Wildcats | Sep. 3 | 7:00 PM | SECN+/ESPN+ | Kroger Field |
| vs Robert Morris Colonials | Sep. 10 | 6:00 PM | ESPN3 | Yager Stadium |
| vs Cincinnati Bearcats | Sep. 17 | 12:00 PM | ESPNU | Paul Brown Stadium |
| @ Northwestern Wildcats | Sep. 24 | TBA | BTN | Ryan Field |
| @ Buffalo Bulls | Oct. 1 | 3:30 PM | TBA | UB Stadium |
| vs Kent State Golden Flashes (HC) | Oct. 8 | TBA | TBA | Yager Stadium |
| @ Bowling Green Falcons | Oct. 15 | TBA | TBA | Doyt Perry Stadium |
| vs Western Michigan Broncos | Oct. 22 | TBA | TBA | Yager Stadium |
| @ Akron Zips | Oct. 29 | TBA | TBA | InfoCision Stadium |
| vs Ohio Bobcats | Nov. 8 | 7/7:30 PM | ESPN2/U/CBSSN | Yager Stadium |
| @ NIU Huskies | Nov. 16 | 6 or 7 PM | ESPN2/ESPNU | Huskie Stadium |
| vs Ball State Cardinals | Nov. 22 | 7:00 PM | ESPNU/ESPN+ | Yager Stadium |
| vs MAC Championship | Dec. 3 | 12:00 PM | ESPN | Ford Field |