| Opponent | Date | Time (ET) | TV | Venues |
| vs Southeastern La. Lions | Sep. 3 | 7:00 PM | ESPN+ | Cajun Field |
| vs Eastern Michigan Eagles | Sep. 10 | 7:00 PM | TV TBA | Cajun Field |
| @ Rice Owls | Sep. 17 | 7:30 PM | ESPN+ | Rice Stadium |
| @ ULM Warhawks | Sep. 24 | 8:00 PM | TBA | Malone Stadium |
| vs South Alabama Jaguars (HC) | Oct. 1 | TBA | TBA | Cajun Field |
| @ Marshall Thundering Herd | Oct. 12 | 7:30 PM | ESPN2 | Joan C. Edwards Stadium |
| vs Arkansas State Red Wolves | Oct. 22 | TBA | TBA | Cajun Field |
| @ Southern Miss Golden Eagles | Oct. 27 | 7:30 PM | ESPNU | M. M. Roberts Stadium |
| vs Troy Trojans | Nov. 5 | TBA | TBA | Cajun Field |
| vs Georgia Southern Eagles | Nov. 10 | 7:30 PM | ESPNU | Cajun Field |
| @ Florida State Seminoles | Nov. 19 | TBA | TBA | Doak Campbell Stadium |
| @ Texas State Bobcats | Nov. 26 | 5:00 PM | TBA | Bobcat Stadium |
| vs Sun Belt Championship | Dec. 3 | 3:30 PM | ESPN | TBD |