| Opponent | Date | Time (ET) | TV | Venues |
| vs South Dakota Coyotes | Sep. 3 | 7:00 PM | ESPN+ | Bill Snyder Family Stadium |
| vs Missouri Tigers | Sep. 10 | 12:00 PM | ESPN2 | Bill Snyder Family Stadium |
| vs Tulane Green Wave | Sep. 17 | 3:00 PM | ESPN+ | Bill Snyder Family Stadium |
| @ Oklahoma Sooners | Sep. 24 | TBA | TBA | Gaylord Family OK Mem. Stadium |
| vs Texas Tech Red Raiders | Oct. 1 | TBA | TBA | Bill Snyder Family Stadium |
| @ Iowa State Cyclones | Oct. 8 | TBA | TBA | Jack Trice Stadium |
| @ TCU Horned Frogs | Oct. 22 | TBA | TBA | Amon G. Carter Stadium |
| vs Oklahoma State Cowboys (HC) | Oct. 29 | TBA | TBA | Bill Snyder Family Stadium |
| vs Texas Longhorns | Nov. 5 | TBA | TBA | Bill Snyder Family Stadium |
| @ Baylor Bears | Nov. 12 | TBA | v | McLane Stadium |
| @ West Virginia Mountaineers | Nov. 19 | TBA | TBA | Mountaineer Field |
| vs Kansas Jayhawks | Nov. 26 | TBA | TBA | Bill Snyder Family Stadium |
| vs Big 12 Championship | Dec. 3 | TBA | ABC | AT&T Stadium |