| Opponent | Date | Time (ET) | TV | Venues |
| vs Southeast Missouri Redhawks | Sep. 3 | 2:00 PM | ESPN+ | Jack Trice Stadium |
| @ Iowa Hawkeyes | Sep. 10 | 4:00 PM | BTN | Kinnick Stadium |
| vs Ohio Bobcats | Sep. 17 | 2:00 PM | ESPN+ | Jack Trice Stadium |
| vs Baylor Bears | Sep. 24 | TBA | TBA | Jack Trice Stadium |
| @ Kansas Jayhawks | Oct. 1 | TBA | TBA | David Booth Kansas Mem. Stadium |
| vs Kansas State Wildcats | Oct. 8 | TBA | TBA | Jack Trice Stadium |
| @ Texas Longhorns | Oct. 15 | TBA | TBA | DKR-Texas Memorial Stadium |
| vs Oklahoma Sooners | Oct. 29 | TBA | FOX or FS1 | Jack Trice Stadium |
| vs West Virginia Mountaineers (HC) | Nov. 5 | TBA | TBA | Jack Trice Stadium |
| @ Oklahoma State Cowboys | Nov. 12 | TBA | TBA | Boone Pickens Stadium |
| vs Texas Tech Red Raiders | Nov. 19 | TBA | TBA | Jack Trice Stadium |
| @ TCU Horned Frogs | Nov. 26 | TBA | TBA | Amon G. Carter Stadium |
| vs Big 12 Championship | Dec. 3 | TBA | ABC | AT&T Stadium |