| Opponent | Date | Time (ET) | TV | Venues |
| vs South Dakota State Jackrabbits | Sep. 3 | 12:00 PM | FS1 | Kinnick Stadium |
| vs Iowa State Cyclones | Sep. 10 | 4:00 PM | BTN | Kinnick Stadium |
| vs Nevada Wolf Pack | Sep. 17 | 7:30 PM | BTN | Kinnick Stadium |
| @ Rutgers Scarlet Knights | Sep. 24 | TBA | TBA | SHI Stadium |
| vs Michigan Wolverines | Oct. 1 | TBA | TBA | Kinnick Stadium |
| @ Illinois Fighting Illini | Oct. 8 | TBA | TBA | Memorial Stadium |
| @ Ohio State Buckeyes | Oct. 22 | TBA | TBA | Ohio Stadium |
| vs Northwestern Wildcats (HC) | Oct. 29 | 3 or 3:30 PM | TBA | Kinnick Stadium |
| @ Purdue Boilermakers | Nov. 5 | TBA | TBA | Ross-Ade Stadium |
| vs Wisconsin Badgers | Nov. 12 | TBA | TBA | Kinnick Stadium |
| @ Minnesota Golden Gophers | Nov. 19 | TBA | TBA | Huntington Bank Stadium |
| vs Nebraska Cornhuskers | Nov. 25 | 4:00 PM | BTN | Kinnick Stadium |
| vs Big Ten Championship | Dec. 3 | 8:00 PM | FOX | Lucas Oil Stadium |