Indianapolis Colts preseason schedule
| Opponent | Date | Time (ET) | TV |
| @ Buffalo Bills | Aug. 13 | 4:00 PM | NFLN |
| vs Detroit Lions | Aug. 20 | 1:00 PM | NFLN |
| vs Tampa Bay Buccaneers | Aug. 27 | 7:30 PM | NFLN |
Indianapolis Colts regular season schedule
| Opponent | Date | Time | TV |
| @ Houston | Sun, 11 Sep | 1:00 PM | CBS |
| @ Jacksonville | Sun, 18 Sep | 1:00 PM | CBS |
| vs Kansas City | Sun, 25 Sep | 1:00 PM | CBS |
| vs Tennessee | Sun, 2 Oct | 1:00 PM | FOX |
| @ Denver | Thu, 6 Oct | 8:15 PM | Prime Video |
| vs Jacksonville | Sun, 16 Oct | 1:00 PM | CBS |
| @ Tennessee | Sun, 23 Oct | 1:00 PM | CBS |
| vs Washington | Sun, 30 Oct | 4:25 PM | FOX |
| @ New England | Sun, 6 Nov | 1:00 PM | CBS |
| @ Las Vegas | Sun, 13 Nov | 4:05 PM | CBS |
| vs Philadelphia | Sun, 20 Nov | 1:00 PM | CBS |
| vs Pittsburgh | Mon, 28 Nov | 8:15 PM | ESPN |
| @ Dallas | Sun, 4 Dec | 8:20 PM | NBC |
| @ Minnesota | Sun, 18 Dec | TBD | TBD |
| vs Los Angeles | Mon, 26 Dec | 8:15 PM | ESPN |
| @ New York | Sat, 1 Jan | 1:00 PM | CBS |
| vs Houston | Sat, 8 Jan | TBD | TBD |