| Opponent | Date | Time (ET) | TV | Venues |
| vs Illinois Fighting Illini | Sep. 2 | 8:00 PM | FS1 | Memorial Stadium |
| vs Idaho Vandals | Sep. 10 | 8:00 PM | BTN | Memorial Stadium |
| vs WKU Hilltoppers | Sep. 17 | 12:00 PM | BTN | Memorial Stadium |
| @ Cincinnati Bearcats | Sep. 24 | TBA | TBA | Nippert Stadium |
| @ Nebraska Cornhuskers | Oct. 1 | 7 or 7:30 PM | TBA | Memorial Stadium |
| vs Michigan Wolverines (HC) | Oct. 8 | 12:00 PM | TBA | Memorial Stadium |
| vs Maryland Terrapins | Oct. 15 | TBA | TBA | Memorial Stadium |
| @ Rutgers Scarlet Knights | Oct. 22 | 12:00 PM | TBA | SHI Stadium |
| vs Penn State Nittany Lions | Nov. 5 | TBA | TBA | Memorial Stadium |
| @ Ohio State Buckeyes | Nov. 12 | TBA | TBA | Ohio Stadium |
| @ Michigan State Spartans | Nov. 19 | TBA | TBA | Spartan Stadium |
| vs Purdue Boilermakers | Nov. 26 | TBA | TBA | Memorial Stadium |
| vs Big Ten Championship | Dec. 3 | 8:00 PM | FOX | Lucas Oil Stadium |