| Opponent | Date | Time (ET) | TV | Venues |
| vs Wyoming Cowboys | Aug. 27 | 4:00 PM | BTN | Memorial Stadium |
| @ Indiana Hoosiers | Sep. 2 | 8:00 PM | FS1 | Memorial Stadium |
| vs Virginia Cavaliers | Sep. 10 | 4:00 PM | ESPNU | Memorial Stadium |
| vs Chattanooga Mocs | Sep. 22 | 8:30 PM | BTN | Memorial Stadium |
| @ Wisconsin Badgers | Oct. 1 | TBA | TBA | Camp Randall Stadium |
| vs Iowa Hawkeyes | Oct. 8 | TBA | TBA | Memorial Stadium |
| vs Minnesota Golden Gophers (HC) | Oct. 15 | 12:00 PM | TBA | Memorial Stadium |
| @ Nebraska Cornhuskers | Oct. 29 | TBA | TBA | Memorial Stadium |
| vs Michigan State Spartans | Nov. 5 | TBA | TBA | Memorial Stadium |
| vs Purdue Boilermakers | Nov. 12 | TBA | TBA | Memorial Stadium |
| @ Michigan Wolverines | Nov. 19 | TBA | TBA | Michigan Stadium |
| @ Northwestern Wildcats | Nov. 26 | TBA | TBA | Ryan Field |
| vs Big Ten Championship | Dec. 3 | 8:00 PM | FOX | Lucas Oil Stadium |