Detroit Lions regular season schedule
| Opponent | Date | Time | TV |
| @ Minnesota | Sun, 25 Sep | 1:00 PM | FOX |
| vs Seattle | Sun, 2 Oct | 1:00 PM | FOX |
| @ New England | Sun, 9 Oct | 1:00 PM | FOX |
| @ Dallas | Sun, 23 Oct | 1:00 PM | CBS |
| vs Miami | Sun, 30 Oct | 1:00 PM | CBS |
| vs Green Bay | Sun, 6 Nov | 1:00 PM | FOX |
| @ Chicago | Sun, 13 Nov | 1:00 PM | FOX |
| @ New York | Sun, 20 Nov | 1:00 PM | FOX |
| vs Buffalo | Thu, 24 Nov | 12:30 PM | CBS |
| vs Jacksonville | Sun, 4 Dec | 1:00 PM | FOX |
| vs Minnesota | Sun, 11 Dec | 1:00 PM | FOX |
| @ New York | Sun, 18 Dec | 1:00 PM | FOX |
| @ Carolina | Sat, 24 Dec | 1:00 PM | FOX |
| vs Chicago | Sat, 1 Jan | 1:00 PM | FOX |
| @ Green Bay | Sat, 8 Jan | TBD | TBD |