Cleveland Brown’s regular-season schedule
| Opponent | Date | Time | TV |
| vs Pittsburgh | Thu, 22 Sep | 8:15 PM | Prime Video |
| @ Atlanta | Sun, 2 Oct | 1:00 PM | CBS |
| vs Los Angeles | Sun, 9 Oct | 1:00 PM | CBS |
| vs New England | Sun, 16 Oct | 1:00 PM | CBS |
| @ Baltimore | Sun, 23 Oct | 1:00 PM | CBS |
| vs Cincinnati | Mon, 31 Oct | 8:15 PM | ESPN |
| @ Miami | Sun, 13 Nov | 1:00 PM | CBS |
| @ Buffalo | Sun, 20 Nov | 1:00 PM | CBS |
| vs Tampa Bay | Sun, 27 Nov | 1:00 PM | FOX |
| @ Houston | Sun, 4 Dec | 1:00 PM | CBS |
| @ Cincinnati | Sun, 11 Dec | 1:00 PM | CBS |
| vs Baltimore | Sun, 18 Dec | TBD | TBD |
| vs New Orleans | Sat, 24 Dec | 1:00 PM | CBS |
| @ Washington | Sat, 1 Jan | 1:00 PM | FOX |
| @ Pittsburgh | Sat, 8 Jan | TBD | TBD |